The strength and quality of innate immune responses varies in response to the environment. In many cases, clear stories predict how these environment/physiology interactions will lead to adaptive changes in an insect's immune response. There are other situations where conditions appear to conspire against the insect and infections induce positive-feedback loops that crash the system. Figure 7.1 illustrates the potential for interactions between immunity and physiology.
To fully understand the immune response of insects we must record and control these environmental variables in our experiments; more than that, we need to understand how these environmental changes alter immunity because some of these environmental effects alter immunity to the same extent as knock-down of the central Toll and Imd signalling pathways.
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