References

Agaisse, H. and Perrimon, N. (2004) The roles of JAK/ STAT signaling in Drosophila immune responses. Immunological Reviews 198, 72-82. Agaisse, H., Petersen, U.M., Boutros, M. et al. (2003) Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Developmental Cell 5, 441-450.

Aggarwal, K., Rus, F., Vriesema-Magnuson, C., Ertuk-Hasdemir, D., Paquette, N. & Silverman, N. (2008). Rudra interrupts receptor signalling complexes to negatively regulate the IMD pathway. PLOS Pathog, 4, e1000120.

Asling, B., Dushay, M., and Hultmark, D. (1995) Identification of early genes in the Drosophila immune response by PCR-based differencial display: the Attacin A gene and the evolution of attacin-like proteins. Insect Biochemistry and Molecular Biology 25, 511-518.

Basset, A., Khush, R., Braun, A. et al. (2000) The phytopath-ogenic bacteria, Erwinia carotovora, infects Drosophila and activates an immune response. Proceedings of the National Academy of Sciences USA 97, 3376-3381.

Belvin, M.P. and Anderson, K.V. (1996) A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annual Review of Cell and Developmental Biology 12, 393-416.

Bischoff, V., Vignal, C., Duvic, B. et al. (2006) Down-regulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS Pathogens 2, e14.

Bogdan, C. (2001) Nitric oxide and the immune response. Nature Immunology 2, 907-916.

Boman, H. (1995) Peptide antibiotics and their role in innate immunity. Annual Review of Immunology 13, 61-92.

Boutros, M., Agaisse, H., and Perrimon, N. (2002) Sequential activation of signaling pathways during innate immune responses in Drosophila. Developmental Cell 3, 711-722.

Buchon, N., Broderick, N. A., Poidevin, M., Praderrand, S. & Lemaitre, B. (2009) Host defense and stem cell proliferation in the gut of bacteria-infected Drosophila. Cell Host Microbe, 5, 200-211.

Brennan, C.A., Delaney, J.R., Schneider, D.S., and Anderson, K.V. (2007) Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Current Biology 17, 67-72.

Bulet, P., Dimarcq, J., Hetru, C. et al. (1993) A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution. Journal of Biological Chemistry 268, 14893-14897.

Busse, M.S., Arnold, C.P., Towb, P. et al. (2007) A kappaB sequence code for pathway-specific innate immune responses. EMBO Journal 26, 3826-3835.

Chang, C.I., Pili-Floury, S., Herve, M. et al. (2004) A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. PLoS Biology 2, E277.

Chang, C.I., Ihara, K., Chelliah, Y. et al. (2005) Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition. Proceedings of the National Academy of Sciences USA 102, 10279-10284.

Chang, C.I., Chelliah, Y., Borek, D. et al. (2006) Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Science 311, 1761-1764.

Choe, K.M., Werner, T., Stoven, S. et al. (2002) Requirement for a peptidoglycan recognition protein (PGRP) in

Relish activation and antibacterial immune responses in Drosophila. Science 296, 359-362.

Cloud-Hansen, K.A., Peterson, S.B., Stabb, E.V. et al. (2006) Breaching the great wall: peptidoglycan and microbial interactions. Nature Reviews Microbiology 4, 710-716.

Corby-Harris, V., Pontaroli, A., Shimkets, L. et al. (2007) Geographical distribution and diversity of bacteria associated with natural populations of Drosophila melanogaster. Applied Environmental Microbiology 73, 3470-3479.

Cox, C. and Gilmore, M. (2007) Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis. Infection and Immunity 75, 1565-1576.

De Gregorio, E., Spellman, P.T., Rubin, G.M., and Lemaitre, B. (2001) Genome-wide analysis of the Drosophila immune response by using oligonucleo-tide microarrays. Proceedings of the National Academy of Sciences USA 98, 12590-12595.

De Gregorio, E., Spellman, P.T., Tzou, P. et al. (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO Journal 21, 2568-2579.

Delaney, J.R., Stoven, S., Uvell, H. et al. (2006) Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways. EMBO Journal 25, 3068-3077.

Dijkers, P.F. and O'Farrell, P.H. (2007) Drosophila cal-cineurin promotes induction of innate immune responses. Current Biology 17, 2087-2093.

Dimarcq, J., Hoffmann, D., Meister, M. et al. (1994) Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity. European Journal of Biochemistry 221, 201-209.

Dostert, C., Jouanguy, E., Irving, P. et al. (2005) The JakSTAT signaling pathway is required but not sufficient for the antiviral response of Drosophila. Nature Immunology 6, 946-953.

Ekengren, S. and Hultmark, D. (1999) Drosophila cecropin as an antifungal agent. Insect Biochemistry and Molecular Biology 29, 965-972.

Ekengren, S., Tryselius, Y., Dushay, M.S. et al. (2001) A humoral stress response in Drosophila. Current Biology 11, 714-718.

Engstrom, Y., Kadalayil, L., Sun, S.C. et al. (1993) kappa B-like motifs regulate the induction of immune genes in Drosophila. Journal of Molecular Biology 232, 327-333.

Fehlbaum, P., Bulet, P., Michaut, L. et al. (1994) Insect immunity: septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. Journal of Biological Chemistry 269, 33159-33163.

Ferrandon, D., Jung, A.C., Criqui, M. et al. (1998) A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO Journal 17, 1217-1227.

Ferrandon, D., Imler, J.L., Hetru, C., and Hoffmann, J.A. (2007) The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nature Reviews Immunology 7, 862-874.

Filipe, S.R., Tomasz, A., and Ligoxygakis, P. (2005) Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway. EMBO Reports 6, 327-333.

Foley, E. and O'Farrell, P.H. (2003) Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes and Development 177 115-125.

Georgel, P., Naitza, S., Kappler, C. et al. (2001) Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Developmental Cell 1, 503-514.

Gesellchen, V., Kuttenkeuler, D., Steckel, M. et al. (2005) An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila. EMBO Reports 6, 979-984.

Gobert, V., Gottar, M., Matskevich, A.A. et al. (2003) Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science 302, 2126-2130.

Gottar, M., Gobert, V., Michel, T. et al. (2002) The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416, 640-644.

Gottar, M., Gobert, V., Matskevich, A. et al. (2006) Dual detection of fungal infections in Drosophila by recognition of glucans and sensing of virulence factors. Cell 127, 1425-1437.

Ha, E.M., Oh, C.T., Bae, Y.S., and Lee, W.J. (2005a) A direct role for dual oxidase in Drosophila gut immunity. Science 310, 847-850.

Ha, E.M., Oh, C.T., Ryu, J.H. et al. (2005b) An antioxidant system required for host protection against gut infection in Drosophila. Developmental Cell 8, 125-132.

Hashimoto, C., Hudson, K., and Anderson, K. (1988) The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52, 269-279.

Hedengren, M., Asling, B., Dushay, M.S. et al. (1999) Relish, a central factor in the control of humoral but not cellular immunity in Drosophila. Molecular Cell 4, 827-837.

Hu, X., Yagi, Y., Tanji, T. et al. (2004) Multimerization and interaction of Toll and Spatzle in Drosophila. Proceedings of the National Academy of Sciences USA 101, 9369-9374.

Hultmark, D. (1996) Insect lysozymes. P, Jolles, ed., Lyzozymes, Model Enzymes in Biochemistry and Biology, pp. 87-102. Birkhäuser, Basel.

Hultmark, D. (2003) Drosophila immunity: paths and patterns. Current Opinion in Immunology 15, 12-19.

Imler, J.L. and Bulet, P. (2005) Antimicrobial peptides in Drosophila: structures, activities and gene regulation. Chemical Immunology and Allergy 86, 1-21.

Ip, Y.T., Reach, M., Engstrom, Y., Kadalayil, L., Cai, H., Gonzalez-Crespo, S., Tatei, K. & Levine, M. (1993) Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell, 75, 753-63.

Irving, P., Troxler, L., Heuer, T.S. et al. (2001) A genome-wide analysis of immune responses in Drosophila. Proceedings of the National Academy of Sciences USA 98, 15119-15124.

Janeway, C. (1989) Evolution and revolution in immunology. Cold Spring Harbor Symposia on Quantitative Biology 54, 1-13.

Jang, I.W., Chosa, N., Kim, S.H. et al. (2006) A Spätzle-processing enzyme required for Toll signaling activation in Drosophila innate immunity. Developmental Cell 10, 45-55.

Kallio, J., Leinonen, A., Ulvila, J. et al. (2005) Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells. Microbes and Infection 7, 811-819.

Kaneko, T., Goldman, W.E., Mellroth, P. et al. (2004) Monomeric and polymeric gram-negative peptidogly-can but not purified LPS stimulate the Drosophila IMD pathway. Immunity 20, 637-649.

Kaneko, T., Yano, T., Aggarwal, K. et al. (2006) PGRP-LC and PGRP-LE have essential yet distinct functions in the Drosophila immune response to monomeric DAP-type peptidoglycan. Nature Immunology 7, 715-723.

Kang, D., Liu, G., Lundstrom, A. et al. (1998) A peptidogly-can recognition protein in innate immunity conserved from insects to humans. Proceedings of the National Academy of Sciences USA 95, 10078-10082.

Kappler, C., Meister, M., Lagueux, M. et al. (1993) Insect immunity. Two 17bp repeats nesting a kB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila. EMBO Journal 12, 1561-1568.

Kim, C.H., Kim, S.J., Kan, H. et al. (2008) A three-step proteolytic cascade mediates the activation of the pep-tidoglycan-induced toll pathway in an insect. Journal of Biological Chemistry 283, 7599-7607.

Kim, M.S., Byun, M., and Oh, B.H. (2003) Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster. Nature Immunology 4, 787-793.

Kim, M., Lee, J.H., Lee, S.Y. et al. (2006) Caspar, a suppressor of antibacterial immunity in Drosophila. Proceedings of the National Academy of Sciences USA 103, 16358-16363.

Kim, T., Yoon, J., Cho, H. et al. (2005) Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. Nature Immunology 6, 211-218.

Kleino, A., Valanne, S., Ulvila, J. et al. (2005) Inhibitor of apoptosis 2 and TAKl-binding protein are components of the Drosophila Imd pathway. EMBO Journal 24, 3423-3434.

Kleino, A., Myllymaki, H., Kallio, J. et al. (2008) Pirk is a negative regulator of the Drosophila Imd pathway. Journal of Immunology 180, 5413-5422.

Krem, M.M. and Cera, E.D. (2002) Evolution of enzyme cascades from embryonic development to blood coagulation. Trends in Biochemical Sciences 27, 67-74.

Lee, W., Lee, J., Kravchenko, V. et al. (1996) Purification and molecular cloning of an inducible Gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proceedings of the National Academy of Sciences USA 93, 7888-7893.

Lemaitre, B. and Hoffmann, J. (2007) The host defense of Drosophila melanogaster. Annual Review of Immunology 25, 697-743.

Lemaitre, B., Kromer-Metzger, E., Michaut, L. et al. (1995) A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proceedings of the National Academy of Sciences USA 92, 9365-9469.

Lemaitre, B., Nicolas, E., Michaut, L. et al. (1996) The dorso-ventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983.

Lemaitre, B., Reichhart, J., and Hoffmann, J. (1997) Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proceedings of the National Academy of Sciences USA 94, 14614-14619.

Leulier, F. and Lemaitre, B. (2008) Toll-like receptors-taking an evolutionary approach. Nature Reviews Genetics 9, 165-178.

Leulier, F., Rodriguez, A., Khush, R.S. et al. (2000) The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Reports 1, 353-358.

Leulier, F., Vidal, S., Saigo, K. et al. (2002) Inducible expression of double-stranded RNA reveals a role for dFADD in the regulatin of the antibacterial response in Drosophila adults. Current Biology 12, 996-1000.

Leulier, F., Parquet, C., Pili-Floury, S. et al. (2003) The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nature Immunology 4, 478-484.

Leulier, F., Lhocine, N., Lemaitre, B., and Meier, P. (2006) The Drosophila IAP DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Molecular and Cellular Biology 26, 7821-7831.

Levashina, E., Ohresser, S., Bulet, P. et al. (1995) Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties. European Journal of Biochemistry 233, 694-700.

Levashina, E. A., Langley, E., Green, C. et al. (1999) Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 285, 1917-1919.

Lhocine, N., Ribeiro, P.S., Buchon, N. et al. (2008) PIMS modulates immune tolerance by negatively regulating Drosophila innate immunity. Cell Host Microbe 4, 147-158.

Liehl, P., Blight, M., Vodovar, N. et al. (2006) Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathogens 2, e56.

Ligoxygakis, P., Pelte, N., Ji, C. et al. (2002) A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO Journal 21, 6330-6337.

Lim, J.H., Kim, M.S., Kim, H.E. et al. (2006) Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. Journal of Biological Chemistry 281, 8286-8295.

Lu, Y., Wu, L.P., and Anderson, K.V. (2001) The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase. Genes and Development 15, 104-110.

Maillet, F., Bischoff, V., Vignal, C. et al. (2008) The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation. Cell Host and Microbe 3, 293-303.

Mcgettigan, J., Mclennan, R.K.J., Broderick, K.E. et al. (2005) Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochemistry and Molecular Biology 35, 741-754.

Medzhitov, R. and Janeway, C.A., JR. (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298.

Mellroth, P., Karlsson, J., Hakansson, J. et al. (2005) Ligand-induced dimerization of Drosophila peptido-glycan recognition proteins in vitro. Proceedings of the National Academy of Sciences USA 102, 6455-6460.

Michel, T., Reichhart, J.M., Hoffmann, J.A., and Royet, J. (2001) Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414, 756-759.

Naitza, S., Rosse, C., Kappler, C. et al. (2002) The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity 17, 575-581.

Nappi, A.J., Vass, E., Frey, F., and Carton, Y. (2000) Nitric oxide involvement in Drosophila immunity. Nitric Oxide 4, 423-430.

Nehme, N.T., Liegeois, S., Kele, B. et al. (2007) A model of bacterial intestinal infections in Drosophila mela-nogaster. PLoS Pathogens 3, e173.

Park, J.M., Brady, H., Ruocco, M.G. et al. (2004) Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes and Development 18, 584-594.

Park, J.W., Kim, C.H., Kim, J.H. et al. (2007) Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Proceedings of the National Academy of Sciences USA 104, 6602-6607.

Pastor-Pareja, J.C., Wu, M. & Xu, T. (2008) An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech., 1, 144-154.

Peng, J., Zipperlen, P., and Kubli, E. (2005) Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Current Biology 15, 1690-1694.

Piao, S., Song, Y.L., Kim, J.H. et al. (2005) Crystal structure of a clip-domain serine protease and functional roles of the clip domains. EMBO Journal 24, 4404-4414.

Rämet, M., Lanot, R., Zachary, D., and Manfruelli, P. (2001) JNK signaling pathway is required for efficient wound healing in Drosophila. Developmental Biology 241, 145-156.

Rämet, M., Manfruelli, P., Pearson, A. et al. (2002) Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 416, 644-648.

Reiser, J.B., Teyton, L., and Wilson, I.A. (2004) Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution. Journal of Molecular Biology 340, 909-917.

Ren, C., Webster, P., Finkel, S.E., and Tower, J. (2007) Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metabolism 6, 144-152.

Royet, J. and Dziarski, R. (2007) Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences. Nature Reviews Microbiology 5, 264-277.

Rutschmann, S., Jung, A.C., Zhou, R. et al. (2000) Role of Drosophila IKKy in a Toll-independent antibacterial immune response. Nature Immunology 1, 342-347.

Rutschmann, S., Kilinc, A., and Ferrandon, D. (2002) Cutting edge: the toll pathway is required for resistance to gram- positive bacterial infections in Drosophila. Journal of Immunology 168, 1542-1546.

Ryu, J.H., Ha, E.M., Oh, C.T. et al. (2006) An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity. EMBO Journal 25, 3693-3701.

Ryu, J.H., Kim, S.H., Lee, H.Y. et al. (2008) Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science 319, 777-782.

Sackton, T.B., Lazzaro, B.P., Schlenke, T.A. et al. (2007) Dynamic evolution of the innate immune system in Drosophila. Nature Genetics 39, 1461-1468.

Scherfer, C., Qazi, M.R., Takahashi, K. et al. (2006) The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation. Developmental Biology 295, 156-163.

Senger, K., Harris, K. & Levine, M. (2006) GATA factors participate in tissue-specific immune responses in Drosophila larvae. Proc Natl Acad Sci USA, 103, 15957-15962.

Shirasu-Hiza, M.M. and Schneider, D.S. (2007) Confronting physiology: how do infected flies die? Cellular Microbiology 9, 2775-2783.

Silverman, N., Zhou, J., Stöven, S. et al. (2000) A Drosophila IkB kinase complex required for Relish cleavage and antibacterial immunity. Genes and Development 14, 2461-2471.

Silverman, N., Zhou, R., Erlich, R.L. et al. (2003) Immune activation of NF-kappaB and JNK requires Drosophila TAK1. Journal of Biological Chemistry 278, 48928-48934.

Steiner, H. (2004) Peptidoglycan recognition proteins: on and off switches for innate immunity. Immunological Reviews 198, 83-96.

Stenbak, C.R., Ryu, J.H., Leulier, F. et al. (2004) Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. Journal of Immunology 173, 7339-7348.

Stöven, S., Ando, I., Kadalayil, L. et al. (2000) Activation of the Drosophila NF-kB factor Relish by rapide endopro-teolytic cleavage. EMBO Reports 1, 347-352.

Takehana, A., Yano, T., Mita, S. et al. (2004) Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act syn-ergistically in Drosophila immunity. EMBO Journal 23, 4690-4700.

Tang, H., Kambris, Z., Lemaitre, B. & Hashimoto, C. (2008) A serpin that regulates the immune melanization in the respiratory system of Drosophila. Dev Cell, 15, 617-626.

Tanji, T., Hu, X., Weber, A.N., and Ip, Y.T. (2007) Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster. Molecular and Cellular Biology 27, 4578-4588.

Tauszig-Delamasure, S., Bilak, H., Capovilla, M. et al. (2002) Drosophila MyD88 is required for the response to fungal and Gram- positive bacterial infections. Nature Immunology 3, 91-97.

Tzou, P., Ohresser, S., Ferrandon, D. et al. (2000) Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 13, 737-748.

Tzou, P., Reichhart, J.M., and Lemaitre, B. (2002) Constitutive expression of a single antimicrobial pep-tide can restore wild-type resistance to infection in immuno-deficient Drosophila mutants. Proceedings of the National Academy of Sciences USA 99, 2152-2157.

Uttenweiler-Joseph, S., Moniatte, M., Lagueux, M. et al. (1998) Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of- flight mass spec-trometry study. Proceedings of the National Academy of Sciences USA 95, 11342-11347.

Uvell, H. and Engstrom, Y. (2007) A multilayered defense against infection: combinatorial control of insect immune genes. Trends in Genetics 23, 342-349.

Vallet-Gely, I., Lemaitre, B., and Boccard, F. (2008) Bacterial strategies to overcome insect defences. Nature Reviews Microbiology 6, 302-313.

Vidal, S., Khush, R.S., Leulier, F. et al. (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes and Development 15, 1900-1912.

Vodovar, N., Vinals, M., Liehl, P. et al. (2005) Drosophila host defense after oral infection by an entomopatho-genic Pseudomonas species. Proceedings of the National Academy of Sciences USA 102, 11414-11419.

Wagner, C., Iserman, K., Fehrenbach, H. & Roeder, T. (2008) Molecular architecture of the fruit fly's airway epithelial immune system. BMC Genomics, 9, 446.

Wang, L., Weber, A.N., Atilano, M.L. et al. (2006) Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO Journal 25, 5005-5014.

Weber, A.N., Tauszig-Delamasure, S., Hoffmann, J.A. et al. (2003) Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling. Nature Immunology 4, 794-800.

Wicker, C., Reichhart, J.M., Hoffmann, D. et al. (1990) Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. Journal of Biological Chemistry 265, 22493-22498.

Yano, T., Mita, S., Ohmori, H. et al. (2008) Autophagic control of listeria through intracellular innate immune recognition in Drosophila. Nature Immunology 9, 908-916.

Yoshida, H., Kinoshita, K., and Ashida, M. (1996) Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx mori. Journal of Biological Chemistry 271, 13854-13860.

Zaidman-Remy, A., Herve, M., Poidevin, M. et al. (2006) The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity 24, 463-473.

Zhuang, Z.H., Sun, L., Kong, L. et al. (2006) Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cellular Signalling 18, 964-970.

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