References

Altincicek, B. and Vilcinskas, A. (2006) Metamorphosis and collagen-IV-fragments stimulate innate immune response in the greater wax moth, Galleria mellon-ella. Developmental and Comparative Immunology 30, 1108-1118.

Altincicek, B., Stotzel, S., Wygrecka, M. et al. (2008) Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation, and prolong survival upon infection in insects. Journal oflmmunology 181, 2705-2712. Ao, J.Q., Ling, E., and Yu, X.Q. (2008) A Toll receptor from Manduca sexta is in response to Escherichia coli infection. Molecular Immunology 45, 543-552. Ashida, M. and Brey, P.T. (1998) Recent advances on the research of the insect prophenoloxidase cascade. In P.T. Brey and D. Hultmark, eds, Molecular Mechanisms of Immune Responses in Insects, pp. 135-172. Chapman & Hall, London.

Beschin, A., Bilej, M., Hanssens, F. et al. (1998) Identification and cloning of a glucan- and lipopolysaccharide-binding protein from Eisenia foetida earthworm involved in the activation of prophenoloxidase cascade. Journal of Biological Chemistry 273, 24948-24954.

Bettencourt, R., Lanz-Mendoza, H., Lindquist, K.R., and Faye, I. (1997) Cell adhesion properties of hemolin, an insect immune protein in the Ig superfamily. European Journal of Biochemistry 250, 630-637.

Bischoff, V., Vignal C., Boneca I.G. et al. (2004) Function of the Drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. Nature Immunology 5, 1175-1180.

Cerenius, L. and Söderhäll, K. (2004) The prophenoloxi-dase-activating system in invertebrates. Immunological Reviews 198, 116-126.

Cerenius, L., Lee, B.L., and Söderhäll, K. (2008) The pro-PO-system: pros and cons for its role in invertebrate immunity. Trends in Immunology 29, 263-271.

Chai, L.Q., Tian, Y.Y., Yang, D.T. et al. (2008) Molecular cloning and characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology 32, 71-83.

Choe, K.M., Werner, T., Stöven, S. et al. (2002) Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 296, 359-362.

Dai, H., Rayaprolu, S., Gong, Y. et al. (2008) Solution structure, antibacterial activity, and expression profile of Manduca sexta moricin. Journal of Peptide Science 14, 855-863.

Dementiev, A., Dobo, J., and Gettins, P.G. (2006) Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase. Journal of Biological Chemistry 281, 3452-3457.

Dickinson, L., Russell, V.W., and Dunn, P.E. (1988) A family of bacteria-regulated cecropin D-like peptides from Manduca sexta. Journal of Biological Chemistry 263, 19424-19429.

Dissing, M., Giordano H., and DeLotto, R. (2001) Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate. EMBO Journal 20, 2387-2393.

Dunn, P.E. (1990) Humoral immunity in insects. BioScience 40, 738-744.

Dunn, P.E., Dai, W., Kanost, M.R., and Geng, C. (1985) Soluble peptidoglycan fragments stimulate antibacterial protein synthesis by fat body from larvae of Manduca sexta. Developmental and Comparative Immunology 9, 559-568.

Dunn, P.E., Bohnert, T.J., and Russell, V. (1994) Regulation of antibacterial protein synthesis following infection and during metamorphosis of Manduca sexta. Annals of the New York Academy of Sciences 712, 117-130.

Dziarski, R. and Gupta, D. (2006) The peptidoglycan recognition proteins (PGRPs). Genome Biology 7, 232.

El Chamy, L., Leclerc, V., Caldelari, I., and Reichhart, J.M. (2008) Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nature Immunology 9, 1165-1170.

Eleftherianos I., Marokhazi, J., Millichap, P.J. et al. (2006a) Prior infection of Manduca sexta with non-pathogenic Escherichia coli elicits immunity to pathogenic Photorhabdus luminescens: roles of immune-related proteins shown by RNA interference. Insect Biochemistry and Molecular Biology 36, 517-525.

Eleftherianos I., Millichap P.J., ffrench-Constant RH., and Reynolds S.E. (2006b) RNAi suppression of recognition protein mediated immune responses in the tobacco hornworm Manduca sexta causes increased susceptibility to the insect pathogen Photorhabdus. Developmental and Comparative Immunology 30, 1099-1107.

Eleftherianos, I., Gökcen, F., Felfoldi, G. et al. (2007) The immunoglobulin family protein hemolin mediates cellular immune responses to bacteria in the insect Manduca sexta. Cellular Microbiology 9, 1137-1147.

Fabrick, J.A., Baker, J.E., and Kanost, M.R. (2003) cDNA cloning, purification, properties, and function of a beta-1,3-glucan recognition protein from a pyralid moth, Plodia interpunctella. Insect Biochemistry and Molecular Biology 33, 579-594.

Fabrick, J.A., Baker, J.E., and Kanost, M.R. (2004) Innate immunity in a pyralid moth: functional evaluation of domains from a beta-1,3-glucan recognition protein. Journal of Biological Chemistry 279, 26605-26611.

Faye, I. and Kanost, M.R. (1998) Function and regulation of hemolin. In P.T. Brey and D. Hultmark, eds, Molecular Mechanisms of Immune Responses in Insects, pp. 173-188. Chapman and Hall, New York.

Faye, I., Pye, A., Rasmuson, T. et al. (1975) Insect immunity II. Simultaneous induction of antibacterial activity and selective synthesis of some hemolymph proteins in diapausing pupae of Hyalophora cecropia and Samia cynthia. Infection and Immunity 12, 1426-1438.

Ferrandon, D., Imler, J.L., Hetru, C., and Hoffmann, J.A. (2007) The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nature Reviews Immunology 7, 862-874.

Gobert, V., Gottar, M., Matskevich, A.A. et al. (2003) Dual activation of the Drosophila Toll pathway by two pattern recognition receptors. Science 302, 2126-2130.

Gorman, M.J., Kankanala, P., and Kanost, M.R. (2004) Bacterial challenge stimulates innate immune responses in extra-embryonic tissues of tobacco horn-worm eggs. Insect Molecular Biology 13, 19-24.

Gorman, M.J., An, C., and Kanost, M.R. (2007a) Characterization of tyrosine hydroxylase from Manduca sexta. Insect Biochemistry and Molecular Biology 37, 1327-1337.

Gorman, M.J., Wang, Y., Jiang, H., and Kanost, M.R. (2007b) Manduca sexta hemolymph proteinase 21 activates prophenoloxidase-activating proteinase 3 in an insect innate immune response proteinase cascade. Journal of Biological Chemistry 282, 11742-11749.

Gottar, M., Gobert, V., Michel, T. et al. (2002) The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416, 640-644.

Gottar, M., Gobert, V., Matskevich, A.A. et al. (2006) Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell 127, 1425-1437.

Gupta, S., Wang, Y., and Jiang. H. (2005) Manduca sexta prophenoloxidase (proPO) activation requires proPO-activating proteinase (PAP) and serine proteinase homologs (SPHs) simultaneously. Insect Biochemistry and Molecular Biology 35, 241-248.

Hall, M., Scott, T., Sugumaran, M. et al. (1995) Proenzyme of Manduca sexta phenol oxidase: purification, activation, substrate specificity of the active enzyme, and molecular cloning. Proceedings of the National Academy of Sciences USA 92, 7764-7768.

Hoffmann, D., Hultmark, D., and Boman, H.G. (1981) Insect immunity: Galleria mellonella and other Lepidoptera have cecropia-P9-like factors active against Gram negative bacteria. Insect Biochemistry 11, 537-548.

Huang, R., Lu, Z., Dai, H. et al. (2007) The solution structure of clip domains from Manduca sexta proph-enoloxidase activating proteinase-2. Biochemistry 46, 11431-11439.

Hultmark, D., Steiner, H., Rasmuson, T., and Boman, H.G. (1980) Insect immunity. Purification and properties of three inducible bactericidal proteins from hemolymph of immunized pupae of Hyalophora cecropia. European Journal of Biochemistry 106, 7-16.

Hultmark, D., Engström A., Andersson, K. et al. (1983) Insect immunity. Attacins, a family of antibacterial proteins from Hyalophora cecropia. EMBO Journal 2, 571-576.

Iketani, M. and Morishima, I. (1993) Induction of antibacterial protein synthesis by soluble peptidogly-can in isolated fat body from larvae of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology 23, 913-917.

Iketani, M., Nishimura, H., Akayama, K. et al. (1999) Minimum structure of peptidoglycan required for induction of antibacterial protein synthesis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology 29, 19-24.

Iwanaga, S. (2007) Biochemical principle of Limulus test for detecting bacterial endotoxins. Proceedings of the Japan Academy, Series B 83, 110-119.

Iwanaga, S. and Lee, B.L. (2005) Recent advances in the innate immunity of invertebrate animals. Journal of Biochemistry and Molecular Biology 8, 128-150. Janeway, Jr, C.A. and Medzhitov, R. (2002) Innate immune recognition. Annual Review of Immunology 20, 197-216.

Jang, I.H., Chosa, N., Kim, S.H. et al. (2006) A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Developmental Cell 10, 45-55.

Ji, C., Wang, Y., Guo, X. et al. (2004) A pattern recognition serine proteinase triggers the prophenoloxidase activation cascade in the tobacco hornworm, Manduca sexta. Journal of Biological Chemistry 279, 34101-34106.

Jiang, H. (2008) The biochemical basis of antimicrobial responses in Manduca sexta. Insect Science 15, 53-66.

Jiang, H. and Kanost, M.R. (1997) Characterization and functional analysis of 12 naturally occurring reactive site variants of serpin-1 from Manduca sexta. Journal of Biological Chemistry 272, 1082-1087.

Jiang, H. and Kanost, M.R. (2000) The clip-domain family of serine proteinases in arthropods. Insect Biochemistry and Molecular Biology 30, 95-105.

Jiang, H., Wang, Y., Huang, Y. et al. (1996) Organization of serpin gene-1 from Manduca sexta: evolution of a family of alternate exons encoding the reactive site loop. Journal of Biological Chemistry 271, 28017-28023.

Jiang, H., Wang, Y., Ma, C., and Kanost, M.R. (1997) Subunit composition of pro-phenol oxidase from Manduca sexta: molecular cloning of subunit proPO-p1. Insect Biochemistry and Molecular Biology 27, 835-850.

Jiang, H., Wang, Y., and Kanost, M.R. (1998) Pro-phenol oxidase activating proteinase from an insect, Manduca sexta: a bacteria-inducible protein similar to Drosophila easter. Proceedings of the National Academy of Sciences USA 95, 12220-12225.

Jiang, H., Wang, Y., Yu, X.Q., and Kanost, M.R. (2003a) Prophenoloxidase-activating proteinase-2 from hemo-lymph of Manduca sexta. A bacteria-inducible serine proteinase containing two clip domains. Journal of Biological Chemistry 278, 3552-3561.

Jiang, H., Wang, Y., Yu, X.Q. et al. (2003b) Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs. Insect Biochemistry and Molecular Biology 33, 1049-1060.

Jiang, H., Ma, C., Lu, Z.Q., and Kanost, M.R. (2004) Beta-1,3-glucan recognition protein-2 (betaGRP-2) from

Manduca sexta; an acute-phase protein that binds beta-1,3-glucan and lipoteichoic acid to aggregate fungi and bacteria and stimulate prophenoloxidase activation. Insect Biochemistry and Molecular Biology 34, 89-100.

Jiang, H., Wang, Y., Gu, Y. et al. (2005) Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph. Insect Biochemistry and Molecular Biology 35, 931-943.

Jiravanichpaisal, P., Lee, B.L., and Söderhäll K (2006) Cell-mediated immunity in arthropods: hematopoi-esis, coagulation, melanization and opsonization. Immunobiology 211, 213-236.

Kambris, Z., Brun, S., Jang, I.H. et al. (2006) Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Current Biology 18, 808-813.

Kan, H., Kim, C.H., Kwon H.M. et al. (2008) Molecular control of phenoloxidase-induced melanin synthesis in an insect. Journal of Biological Chemistry 283, 25316-25323.

Kang, D., Liu, G., Lundström, A. et al. (1998) A peptidogly-can recognition protein in innate immunity conserved from insects to humans. Proceedings of the National Academy of Sciences USA 95, 10078-10082.

Kanost, M.R. (1999) Serine proteinase inhibitors in arthropod immunity. Developmental and Comparative Immunology 23, 291-301.

Kanost, M.R. (2007) Serpins in a Lepidopteran insect, Manduca sexta. In G.A. Silverman and D.A. Lomas, eds, The Serpinopathies: Molecular and Cellular Aspects of Serpins and their Disorders, pp. 229-242. World Scientific Publishing Co. Hackensack, NJ.

Kanost, M.R. and Gorman, M.J. (2008) Phenoloxidases in insect immunity. In N.E. Beckage, ed., Insect Immunology, pp. 69-96 Elsevier, San Diego, CA.

Kanost, M.R. and Nardi, J. (2008) Innate immune responses of Manduca sexta. In M.R. Goldsmith and F. Marec, eds, Molecular Biology and Genetics of Lepidoptera. CRC Press, Boca Raton, FL (in press).

Kanost, M.R., Dai, W., and Dunn, P.E. (1988) Peptidoglycan fragments elicit antibacterial protein synthesis in larvae of Manduca sexta. Archives of Insect Biochemistry and Physiology 8, 147-164.

Kanost, M.R., Kawooya, J.K., Law, J.H. et al. (1990) Insect haemolymph proteins. In P.D. Evans and V.B. Wigglesworth, eds, Advances in Insect Physiology, pp. 299-396. Academic Press, San Diego, CA.

Kanost, M.R., Prasad, S.V., Huang, Y., and Willott, E. (1995) Regulation of serpin gene-1 in Manduca sexta. Insect Biochemistry and Molecular Biology 25, 285-291.

Kanost, M.R., Jiang, H., and Yu, X.Q. (2004) Innate immune responses of a lepidopteran insect, Manduca sexta. Immunological Reviews 198, 97-105.

Kim, C.H., Kim, S.J., Kan, H. et al. (2008) A three-step proteolytic cascade mediates the activation of the peptidoglycan-induced toll pathway in an insect. Journal of Biological Chemistry 283, 7599-7607.

Kim, M.H., Joo, C.H., Cho, M.Y. et al. (2000a) Bacterial-injection-induced syntheses of N-beta-alanyldopamine and Dopa decarboxylase in the hemolymph of coleop-teran insect, Tenebrio molitor larvae. European Journal of Biochemistry 267, 2599-2608.

Kim, Y.S., Ryu, J.H., Han, S.J. et al. (2000b) Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. Journal of Biological Chemistry 275, 32721-32727.

Koizumi, N., Imai, Y., Morozumi, A. et al. (1999) Lipopolysaccharide-binding protein of Bombyx mori participates in a hemocyte-mediated defense reaction against Gram-negative bacteria. Journal of Insect Physiology 45, 853-859.

Kurata, S., Ariki, S., and Kawabata, S. (2006) Recognition of pathogens and activation of immune responses in Drosophila and horseshoe crab innate immunity. Immunobiology 211, 237-249.

Ladendorff, N.E. and Kanost, M.R. (1991) Bacteria-induced protein P4 (hemolin) from Manduca sexta: a member of the immunoglobulin superfamily which can inhibit hemocyte aggregation. Archives of Insect Biochemistry and Physiology 18, 285-300.

Lee, S.Y., Wang, R., and Söderhäll, K. (2000) A lipopoly-saccharide and ß-1,3-glucan binding protein form hemocytes of the freshwater crayfish Pacifastacus leni-usculus: purification, characterization, and cDNA cloning. Journal of Biological Chemistry 275, 1337-1343.

Lee, W.J., Lee, J.D., Kravchenko, V.V. et al. (1996) Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proceedings of the National Academy of Sciences USA 93, 7888-7893.

Lemaitre, B. and Hoffmann, J. (2007) The host defense of Drosophila melanogaster. Annual Review of Immunology 25, 697-743.

LeMosy, E.K., Tan, Y.Q., and Hashimoto, C. (2001) Activation of a protease cascade involved in patterning the Drosophila embryo. Proceedings of the National Academy of Sciences USA 98, 5055-5060.

Leone P., Bischoff, V., Kellenberger C. et al. (2008) Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan. Molecular Immunology 45, 2521-2530.

Ligoxygakis, P., Pelte, N., Hoffmann, J.A., and Reichhart, J.M. (2002) Activation of Drosophila Toll during fungal infection by a blood serine protease. Science 297, 114-116.

López-Zavala, A.A., de-la-Re-Vega, E., Calderón-Arredondo, S.A. et al. (2004) Biophysical characterization of an insect lysozyme from Manduca sexta. Protein and Peptide Letters 11, 85-92.

Ma, C. and Kanost, M.R. (2000) A beta-1,3-glucan recognition protein from an insect, Manduca sexta, agglutinates microorganisms and activates the phenoloxidase cascade. Journal of Biological Chemistry 275, 7505-7514.

Matzinger, P. (2002) The danger model: a renewed sense of self. Science 296, 301-305.

Michel, K., Suwanchaichinda, C., Morlais, I. et al. (2006) Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum. Proceedings of the National Academy of Sciences USA 103, 16858-16863.

Michel, T., Reichhart, J.M., Hoffmann, J.A., and Royet, J. (2001) Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414, 756-759.

Mulnix, A.B. and Dunn, P.E. (1994) Structure and induction of a lysozyme gene from the tobacco hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology 24, 271-281.

Nappi, A.J. and Christensen, B.M. (2005) Melanogenesis and associated cytotoxic reactions: applications to insect innate immunity. Insect Biochemistry and Molecular Biology 35, 443-459.

Ochiai, M. and Ashida, M. (1988) Purification of a ß-1,3-glucan recognition protein in the prophenoloxidase system from hemolymph of the silkworm, Bombyx mori. Journal of Biological Chemistry 263, 12056-12062.

Ochiai, M. and Ashida, M. (1999) A pattern recognition protein for peptidoglycan. Cloning the cDNA and the gene of the silkworm, Bombyx mori. Journal of Biological Chemistry 274, 11854-11858.

Ochiai, M. and Ashida, M. (2000) A pattern-recognition protein for ß-1,3-glucan: the binding domain and the cDNA cloning of ß-1,3-glucan recognition protein from the silkworm, Bombyx mori. Journal of Biological Chemistry 275, 4995-5002.

Onoe, H., Matsumoto, A., Hashimoto, K. et al. (2007) Peptidoglycan recognition protein (PGRP) from eri-silkworm, Samia cynthia ricini; protein purification and induction of the gene expression. Comparative Biochemistry and Physiology B 147, 512-519.

Park, J.W., Kim, C.H., Kim, J.H. et al. (2007) Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Proceedings of the National Academy of Science USA 104, 6602-6607.

Piao, S., Song, Y.L., Kim, J.H. et al. (2005) Crystal structure of a clip-domain serine protease and functional roles of the clip domains. EMBO Journal 24, 4404-4414.

Pili-Floury, S., Leulier, F., Takahashi, K. et al. (2004) In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults. Journal of Biological Chemistry 279, 12848-12853.

Powning, R.F. and Davidson, W.J. (1973) Studies of insect bacteriolytic enzymes-I. Lysozyme in haemolymph of Galleria mellonella and Bombyx mori. Comparative Biochemistry and Physiology 45B, 669-686.

Ragan, E.J. (2008) Immune-related Protein Complexes and Serpin-1 Isoforms in Manduca sexta Plasma. PhD dissertation, Kansas State University.

Reichhart, J.M. (2005) Tip of another iceberg: Drosophila serpins. Trends in Cell Biology 15, 659-665.

Rose, T., LeMosy E.K., Cantwell, A.M. et al. (2003) Three dimensional models of proteases involved in patterning of the Drosophila embryo. Journal of Biological Chemistry 278, 11320-11330.

Ross, J., Jiang, H., Kanost, M.R., and Wang, Y. (2003) Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationship. Gene 304, 117-131.

Sansonetti, P.J. (2006) The innate signaling of dangers and the dangers of innate signaling. Nature Immunology 7, 1237-1242.

Schleifer, K.H. and Kandler, O. (1972) Peptidoglycan types of bacterial cell walls and their taxonomic implications. Microbiology and Molecular Biology Reviews 36, 407-477.

Sen, J., Goltz, J.S., Stevens L., and Stein, D. (1998) Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity. Cell 95, 471-481.

Shin, S.W., Park, D.S., Kim, S.C., and Park, H.Y. (2000) Two carbohydrate recognition domains of Hyphantria cunea lectin bind to bacterial lipopolysaccharides through O-specific chain. FEBS Letters 467, 70-74.

Silverman, G.A., Bird, P.I., Carrell, R.W. et al. (2001) The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. Journal of Biological Chemistry 276, 33293-33296.

Steiner, H., Hultmark, D., Engström, A. et al. (1981) Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292, 246-248.

Stevens, J.M. (1962) Bactericidal activity of the blood of actively immunized wax moth larvae. Canadian Journal of Microbiology 8, 491-499.

Su, X.D., Gastinel, L.N., Vaughn, D.E. et al. (1998) Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion. Science 281, 991-995.

Takehana, A., Katsuyama, T., Yano, T. et al. (2002) Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/ relish-mediated antibacterial defense and the proph-enoloxidase cascade in Drosophila larvae. Proceedings of the National Academy of Sciences USA 99, 13705-13710.

Takehana, A., Yano, T., Mita, S. et al. (2004) Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act syn-ergistically in Drosophila immunity. EMBO Journal 23, 4690-4700.

Tanaka H., Ishibashi, J., Fujita, K. et al. (2008) A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori. Insect Biochemistry and Molecular Biology doi: 10.1016/j.ibmb.2008.09.001.

Terenius, O. (2008) Hemolin-A lepidopteran antiviral defense factor? Developmental and Comparative Immunology 32, 311-316.

Tong, Y. and Kanost, M.R. (2005) Manduca sexta serpin-4 and serpin-5 inhibit the prophenol oxidase activation pathway: cDNA cloning, protein expression, and characterization. Journal of Biological Chemistry 280, 14923-14931.

Tong, Y., Jiang, H. and Kanost, M.R. (2005) Identification of plasma proteases inhibited by Manduca sexta serpin-4 and serpin-5 and their association with components of the prophenol oxidase activation pathway. Journal of Biological Chemistry 280, 14932-14942.

Tzou, P., Reichhart J.M., and Lemaitre, B. (2002) Constitutive expression of a single antimicrobial pep-tide can restore wild-type resistance to infection in immunodeficient Drosophila mutants. Proceedings of the National Academy of Sciences USA 99, 2152-2157.

Wang, L. and Ligoxygakis, P. (2006) Pathogen recognition and signalling in the Drosophila innate immune response. Immunobiology 211, 251-261.

Wang, L., Weber, A.N., Atilano, M.L. et al. (2006) Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO Journal 25, 5005-5014.

Wang, L., Gilbert, R.J., Atilano, M.L. et al. (2008) Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity. Proceedings of the National Academy of Sciences USA 105, 11881-11886.

Wang, Y. and Jiang, H. (2004a) Prophenoloxidase (proPO) activation in Manduca sexta: an analysis of molecular interactions among proPO, proPO-activating proteinase-3, and a cofactor. Insect Biochemistry and Molecular Biology 34, 731-742.

Wang, Y. and Jiang, H. (2004b) Purification and characterization of Manduca sexta serpin-6: a serine proteinase inhibitor that selectively inhibits prophenoloxidase-activating proteinase-3. Insect Biochemistry and Molecular Biology 34, 387-395.

Wang, Y. and Jiang, H. (2006) Interaction of beta-1,3-glu-can with its recognition protein activates hemolymph proteinase 14, an initiation enzyme of the prophe-noloxidase activation system in Manduca sexta. Journal of Biological Chemistry 281, 9271-9278.

Wang, Y. and Jiang, H. (2007) Reconstitution of a branch of the Manduca sexta prophenoloxidase activation cascade in vitro: snake-like hemolymph proteinase 21 (HP21) cleaved by HP14 activates prophenoloxidase-activating proteinase-2 precursor. Insect Biochemistry and Molecular Biology 37, 1015-1025.

Wang, Y. and Jiang, H. (2008) A positive feedback mechanism in the Manduca sexta prophenoloxidase activation system. Insect Biochemistry and Molecular Biology 38, 763-769.

Wang, Y., Cheng, T., Rayaprolu, S. et al. (2007) Proteolytic activation of pro-spätzle is required for the induced transcription of antimicrobial peptide genes in lepi-dopteran insects. Developmental and Comparative Immunology 31, 1002-1012.

Watanabe, A., Miyazawa S., Kitami M. et al. (2006) Characterization of a novel C-type lectin, Bombyx mori multibinding protein, from the B. mori hemolymph. Journal of Immunology 177, 4594-4604.

Waterhouse, R.M., Kriventseva, E.V., Meister, S. et al. (2007) Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science 316, 1738-1743.

Werner, T., Liu, G., Kang, D., Ekengren, S. et al. (2000) A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 97, 13772-13777.

Whisstock, J.C. and Bottomley, S.P. (2006) Molecular gymnastics: serpin structure, folding and misfolding. Current Opinion in Structural Biology 16, 761-768.

Ye, S., Cech, A.L., Belmares, R. et al. (2001) The structure of a Michaelis serpin-protease complex. Nature Structural Biology 8, 979-983.

Yoshida, H., Ochai, M., and Ashida, M. (1986) ß-1,3-Glucan receptor and peptidoglycan receptor are present as separate entities within insect prophenoloxidase activating system. Biochemistry and Biophysics Research Communications 114, 1177-1183.

Yoshida, H., Kinoshita, K., and Ashida, M. (1996) Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx mori. Journal of Biological Chemistry 271, 13854-13860.

Yu, X.Q. and Kanost, M.R. (1999) Developmental expression of Manduca sexta hemolin. Archives of Insect Biochemistry and Physiology 42, 198-212.

Yu, X.Q. and Kanost, M.R. (2000) Immulectin-2, a lipo-polysaccharide-specific lectin from an insect, Manduca sexta, is induced in response to gram-negative bacteria. Journal of Biological Chemistry 275, 37373-37381.

Yu, X.Q. and Kanost, M.R. (2002) Binding of hemolin to bacterial lipopolysaccharide and lipoteichoic acid. An immunoglobulin superfamily member from insects as a pattern-recognition receptor. European Journal of Biochemistry 269, 1827-1834.

Yu, X.Q. and Kanost, M.R. (2003) Manduca sexta lipo-polysaccharide-specific immulectin-2 protects larvae from bacterial infection. Developmental and Comparative Immunology 27, 189-196.

Yu, X.Q. and Kanost, M.R. (2004) Immulectin-2, a pattern recognition receptor that stimulates hemocyte encapsulation and melanization in the tobacco horn-worm, Manduca sexta. Developmental and Comparative Immunology 28, 891-900.

Yu, X.Q. and Ma, Y. (2006) Calcium is not required for immulectin-2 binding, but protects the protein from proteinase digestion. Insect Biochemistry and Molecular Biology 36, 505-516.

Yu, X.Q., Gan, H., and Kanost, M.R. (1999) Immulectin, an inducible C-type lectin from an insect, Manduca sexta, stimulates activation of plasma prophenol oxidase. Insect Biochemistry and Molecular Biology 29, 585-597.

Yu, X.Q., Zhu, Y.F., Ma, C. et al. (2002) Pattern recognition proteins in Manduca sexta plasma. Insect Biochemistry and Molecular Biology 32, 1287-1293.

Yu, X.Q., Jiang, H., Wang, Y., and Kanost, M.R. (2003) Nonproteolytic serine proteinase homologs involved in phenoloxidase activation in the tobacco hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology 33, 197-208.

Yu, X.Q., Tracy, M.E., Ling, E. et al. (2005) A novel C-type immulectin-3 from Manduca sexta is translocated from hemolymph into the cytoplasm of hemocytes. Insect Biochemistry and Molecular Biology 35, 285-295.

Yu, X.Q., Ling, E., Tracy, M.E., and Zhu, Y. (2006) Immulectin-4 from the tobacco hornworm Manduca sexta binds to lipopolysaccharide and lipoteichoic acid. Insect Molecular Biology 15, 119-128.

Zhao, P., Li, J., Wang, Y., and Jiang, H. (2007) Broad-spectrum antimicrobial activity of the reactive compounds generated in vitro by Manduca sexta phe-noloxidase. Insect Biochemistry and Molecular Biology 37, 952-959.

Zhu, Y., Johnson, T., and Kanost, M.R. (2003a) Identification of differentially expressed genes in the immune response of the tobacco hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology 33, 541-559.

Zhu, Y., Wang, Y., Gorman, M.J. et al. (2003b) Manduca sexta serpin-3 regulates prophenoloxidase activation in response to infection by inhibiting prophenoloxidase-activating proteinases. Journal of Biological Chemistry 278, 46556-46564.

Zhuang, S., Kelo, L., Nardi, J.B., and Kanost, M.R. (2007) Neuroglian on hemocyte surfaces is involved in homophilic and heterophilic interactions of the innate immune system of Manduca sexta. Developmental and Comparative Immunology 31, 1159-1167.

Zou, Z. and Jiang, H. (2005) Manduca sexta serpin-6 regulates immune serine proteinases PAP-3 and HP8. cDNA cloning, protein expression, inhibition kinetics, and function elucidation. Journal of Biological Chemistry 280, 14341-14348.

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