Clinical picture

The clinical picture of Lyme disease can be quite complex, consisting of the early skin manifestation known as erythema migrans (EM), as well as potentially more serious sequelae that result from hematogenous dissemination of the spirochete (Wormser, 2006). The more serious clinical sequelae involve the joints, nervous system, and/or heart (Nadelman and Wormser, 1998; Steere, 2001; Stanek and Strle, 2003). Knowledge of the broad clinical spectrum of Lyme disease is an essential component for proper diagnosis and, consequently, effective treatment.

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