Factors that affect toxicity of individual HHCs are increasing numbers of halogens in the molecule, increasing the size of the molecule, increasing ease of homolytic cleavage, electronegativity of halogens, and/or their chain length.
Differences in closely related compounds, such as positional isomers (Table 8) and functional groups, have pronounced effects on ecodisposition, bioconcentration, biodispersion, and biological effects. These major differences within subsets of generic properties are important in understanding the ecotoxicology of HHCs. The relation between structure, metabolism, and toxic action for one subgroup of HHCs may not be duplicatable in other groups. So caution must be taken in conclusively generalizing from experimental deductions.
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