Cholera

Cholera (and other water borne disease; see Brookhart et a/. (2002)) is an extremely interesting disease for a number of reasons. The pathogen itself has a remarkable life history (Faruque et a/. 2003, Reidl and Klose 2002, Yildiz and Schoolnik 1999), switching between two morphs (smooth and rugose) for reasons that we still do not understand. Second, the disease has a free-living stage, in stagnant water, that is key to transmission patterns (Codeco 2000). Third, the potential effects of climate change on cholera dynamics are profound (Lipp et a/. 2002, Cottingham et a/. 2003). Brookhart et a/. (2002) also couple evolution of virulence and host demography in a different way than we did in the text.

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