Vectorbased models

Anderson and May (1991) describe a number of elaborations of the basic model for malaria. Two interesting additional directions are these. First, recall that within the human host, the P/asmodz'wm parasite has separate sexes. This suggests the possibility of local mate competition and sex ratios that deviate from 50:50. Read et a/. (1992, 1995) recognized this possibility and applied an extension of Hamilton's sex ratio theory to P/asmodz'wm. The development of resistance in P/asmodz'wm to antimalarial drugs is another topic of considerable interest and opportunity for modeling (Lipp et a/. 2002, Hastings 1997, 2001, Hastings and McKinnon 1998, Hastings and D'Allesandro 2000, Hastings et a/. 2002) and opportunities exist for new kinds of approaches to drug therapy (Austin et a/. 1998, Gardner 2000, 2001). Roitberg and Friend (1992) initiated a study of the behavioral ecology of the mosquito vector, using a combination of experiments and theory (mainly based on stochastic dynamic programming) to examine host seeking behavior in the vector. Ross's original papers (Ross 1916, Ross and Hudson 1917a, b) can be obtained at JSTOR and are well worth looking at. Catteruccia et a/. (2003) model the effects of genetically modified mosquitoes.

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