Method of administration Rate of administration Age Sex
Body weight Body fat
Psychological status Immunological status Genetic
Presence of other diseases Pollutant pH and ionic states Pollutant physical state Chemical milieau Weather conditions
Larger doses correspond to more immediate effects
Some compounds nontoxic by one route and lethal by another (e.g., phosgene)
Metabolism and excretion keep pollutant concentrations below toxic levels
Elderly and children more susceptible
Each sex has hormonally controlled hypersensitivities
Fat bioconcentrates some compounds (large doses can occur in dieters due to stored pollutants) Stress increases vulnerability Influences metabolism Different metabolic rates
Similar to immunological status; could be a factor in cancer recurrence Interferes or facilitates absorption into the body Compounds absorbed on particulates may be retained at higher rate Synergisms, antagonisms, cancer "promoters," enhanced absorption Temperature, humidity, barometric pressure, and season enhance absorption
It should be noted that scientists cannot measure zero concentration of a chemical—zero concentration is not a scientifically verifiable number. Instead, the terms "nothing detected" or "below the limit of measurement techniques" are used.
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